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Characterization of macrophage/microglial activiation and effect of photobiomodulation in the spared nerve injury model of neuropathic pain

Author: Ketz AK, Byrnes KR, Grunberg NE, Kasper CE, Osborne L, Pryor B, Tosini NL, Wu X, Anders JJ

A Spared Nerve Injury model was performed on rats and mechanical allodynia was assessed with an electronic Von Frey device. A 980 nm CW laser was used for photobiomodulation (PBM) treatment. PBM treated animals began to recover after 2 treatments. The peripheral nerve injury caused an increase in pro-inflammatory microglial activation and PBM caused an increase in anti-inflammatory macrophage/microglial activity.

PublishedPain Medicine. 2016: Published online ahead of print. pnw144. doi: 10.1093/pm/pnw144
Keywords:  Photobiomodulation; Neuropathic Pain; Macrophage; Microglia; Spared Nerve Injury;
Inflammation

About the author(s)

Ketz AK, Byrnes KR, Grunberg NE, Kasper CE, Osborne L, Pryor B, Tosini NL, Wu X, Anders JJ

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