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Intracellular signaling cascades following light irradiation

This paper reviews the available literature on molecular signaling pathways involved in photobiomodulation therapy stimulation for the enhancement of cell proliferation, differentiation, or apoptosis in various indications. The pathways through activating receptor tyrosine kinases are also highlighted in LLLT-induced neuroprotection, wound healing, and skeletal muscle regeneration.
Published:  Laser Photonics Rev. 2014; 8(1): 115–130. doi: 10.1002/lpor.201300015

Published: Laser Photonics Rev. 2014; 8(1): 115–130. doi: 10.1002/lpor.201300015
Author(s): Wu S, Xing D

Effect of diode laser in the treatment of patients with nonspecific chronic low back pain: a randomized controlled trial

Study to evaluate pain reduction efficacy of treatment with GaAlAs laser (980 nm) with a large diameter spot size combined with exercise. The study evaluated 100 patients with chronic low back pain. At the end of the 3 week period, the Laser + exercise group showed a significantly greater decrease in pain than did the [...]

Published: Photomedicine and Laser Surgery. 2014; 32(9): 490-494.
Author(s): Vallone F, Benedicenti S, Sorrenti E, Schiavetti I, Angiero A

Low level laser treatment of tendinopathy: a systematic review with meta-analysis

Review of clinical trials of laser therapy for the treatment of tendinopathy.  Dosages used in the 12 positive studies would support the existence of an effective dosage window that closely resembled current recommended guidelines. Conclusion: LLLT can potentially be effective in treating tendinopathy when recommended dosages are used.
Published:  Photomedicine and Laser Surgery. 2010; 28(1): 3-16. [...]

Published: Photomedicine and Laser Surgery. 2010; 28(1): 3-16. doi: 10.1089=pho.2008.2470
Author(s): Tumilty S, Munn J, McDonough S, Hurley DA, Basford JR, Baxter GD

Quantitative analysis of transcranial and intraparenchymal light penetration in human cadaver brain tissue

This study investigated the light penetration gradients in the human cadaver brain using a Transcranial Laser System with a 30 mm diameter beam of 808 nm wavelength light. In addition, the wavelength dependence of light scatter and absorbance in intraparenchymal brain tissue using 660, 808, and 940 nm wavelengths was investigated. Transcranial application of 808 [...]

Published: Lasers in Surgery and Medicine. 2015; 47(4): 312-322. doi 10.1002/lsm.22343
Author(s): Tedford CE, DeLapp S, Jacques S, Anders J

Short-term effects of high-intensity laser therapy versus ultrasound therapy in the treatment of people with subacromial impingement syndrome: a randomized clinical trial

Randomized controlled trial of laser therapy vs. therapeutic ultrasound in 70 patients with clinically verified subacromial impingement syndrome. Laser therapy was shown to have significantly greater benefit than ultrasound in reducing pain and improving the articular movement, functionality and muscle strength of the affected shoulder.
Published:  Phys Ther. 2009; 89(7): 643-652.

Published: Phys Ther. 2009; 89(7): 643-652.
Author(s): Santamato A, Solfrizzi V, Panza F, Tondi G, Frisardi V, Leggin BG, Ranieri M, Fiore P

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