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Biphasic dose response in low level light therapy

This review paper covers the current theory on basic mechanisms of laser therapy and discusses the effects of different dosing strategies. Cytochrome c is identified as the primary absorber of light in the near infrared leading to cellular changes related to ATP, NO and ROS levels. Different doses of laser therapy are shown to either [...]

Published: Dose-Response. 2009; 7(4): 358–383. doi: 10.2203/dose-response.09-027.Hamblin
Author(s): Huang Y-Y, Chen AC-H, Carroll JD, Hamblin MR

Effect of pulsing in low-level light therapy

Review of 33 studies comparing CW and pulsed laser treatments.  A common criticism of these studies is the lack of direct, like-for-like comparison of pulsed treatment to CW.  The article concludes “CW is the gold standard and has been used for all LLLT applications” and “there is no consensus on the effects of different frequencies [...]

Published: Lasers Surg Med. 2010; 42(6): 450–466. doi:10.1002/lsm.20950.
Author(s): Hashmi JT, Huang Y-Y, Sharma SK, Kurup DB, De Taboada L, Carroll JD, Hamblin MR

The bone and joint decade 2000–2010 task force on neck pain and its associated disorders

World Health Organization (WHO) taskforce concludes that laser therapy is beneficial for the treatment of neck pain.

Published: Spine. 2008; 33(4S): S5-S7. doi: 10.1097/BRS.0b013e3181643f40.
Author(s): Haldeman S, Carroll L, Cassidy JD, Schubert J, Nygren Å

Low-level laser irradiation (InGaAlP-660 nm) increases fibroblast cell proliferation and reduces cell death in a dose-dependent Manner

In cell culture, primary fibroblasts treated with laser at 660 nm were shown to increase proliferation and decrease cell death at an irradiance of 2.5 W/cm2 and a fluence of 150 J/cm2.
Published:  Photomedicine and Laser Surgery. 2010; 28(S1): S151-S156. doi: 10.1089=pho.2008.2475

Published: Photomedicine and Laser Surgery. 2010; 28(S1): S151-S156. doi: 10.1089=pho.2008.2475
Author(s): Frigo L, Favero GM, Lima HJC, Maria DA, Bjordal JM, Joensen J, Iversen VV, Marcos RL, Parizzoto NA, Lopes-Martins RAB

Frozen shoulder: the effectiveness of conservative and surgical interventions— systematic review

Systematic review to evaluate the effectiveness of multiple conservative and surgical interventions for frozen shoulder.  The analysis found strong evidence for the use of laser therapy for short term pain relief.
Published:  British Journal of Sports Medicine. 2011; 45(1): 49-56. doi: 10.1136/bjsm.2010.071431

Published: British Journal of Sports Medicine. 2011; 45(1): 49-56. doi: 10.1136/bjsm.2010.071431
Author(s): Favejee MM, Huisstede BMA, Koes BW

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