Studies
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Changes in absorbance of monolayer of living cells induced by laser radiation at 633, 670, and 820 nm
Absorption changes in HeLa cells were evaluated from 530-890 nm. Cytochrome c oxidase becomes more oxidized (implying increased cellular oxidative metabolism) at all wavelengths used. This study supports the hypothesis that the mechanism of photobiomodulation is related to the chromophore cytochrome c.
Published: IEEE Journal on Selected Topics In Quantum Electronics. 2001; 7(6): 982-988.
Keywords: cytochrome c [...]
Photobiomodulation in context of new data about multiple roles of ATP
Editorial on mechanisms of photobiomodulation with emphasis on new discoveries that ATP is not only the energy inside cells but also a critical signaling molecule that allows cells and tissues to communicate with one another.
Published: Photomedicine and Laser Surgery. 2010; 28(2): 159-160. doi: 10.1089/pho.2010.2789
Low-power laser therapy
Chapter on laser therapy written by one of the pioneers in the field of photobiomodulation.
Published: In: Vo-Dinh T, editor. Biomedical Photonics Handbook. Boca Raton (FL) CRC Press; 2003: 48-1-48-25.
Biphasic dose response in low level light therapy–an update
Update on review paper for bi-phasic dose response (https://www.litecure.com/blog/studies/biphasic-dose-response-in-low-level-light-therapy/).
Published: Dose-Response. 2011; 9: 602-618. doi: 10.2203/dose-response.11-009.11-009.Hamblin
Keywords: low level laser therapy, photobiomodulation, biphasic dose response, reactive oxygen species, nitric oxide, traumatic brain injury
Biphasic dose response in low level light therapy
This review paper covers the current theory on basic mechanisms of laser therapy and discusses the effects of different dosing strategies. Cytochrome c is identified as the primary absorber of light in the near infrared leading to cellular changes related to ATP, NO and ROS levels. Different doses of laser therapy are shown to either [...]
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