The effect of platelet-rich plasma on patterns of gene expression in a dog model of anterior cruciate ligament reconstruction

Published:  J Surg Res. 2013 Mar;180(1):80-8. doi: 10.1016/j.jss.2012.10.036. Epub 2012 Nov 8.

Authors:  Xie X, Wu H, Zhao S, Xie G, Huangfu X, Zhao J.

Summary:  This study investigated the influence of PRP on the synthesis and degradation of the extracellular matrix during the ACL graft remodeling process. The results indate  a time-dependent change of gene expression following ACL reconstruction surgery.Results demonstrate that PRP alters the expression of some target genes at certain time points, especially during the early stages of graft remodeling, which might explain the enhancing effect of PRP on the ACL graft maturation process.

Key words:  Platelet-rich plasma, Gene expression, Ligamentization, Extracellular matrix

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