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Laser photobiomodulation of gene expression and release of growth factors and cytokines from cells in culture: a review of human and animal studies

The aim of this paper was to review experimental studies of laser irradiation of human and animal cells in culture to assess the photobiomodulatory effects of such irradiation on gene expression and release of growth factors and CYTOKINES.

Published: Photomedicine and Laser Surgery. 2011; 29(5): 285-304. doi: 10.1089/pho.2010.2846
Author(s): Peplow PV, Chung T-Y, Ryan B, Baxter GD

Short-term effects of high-intensity laser therapy versus ultrasound therapy in the treatment of low back pain: a randomized controlled trial

30 consecutive patients with clinically verified sub-acute or chronic low back pain were randomized to receive 15 treatments (5 days a week for 3 weeks) of either ultrasound or laser therapy.

Published: Eur J Phys Rehabil Med. 2011; 47(3): 367-373.
Author(s): Fiore P, Panza F, Cassatella G, Russo A, Frisardi V, Solfrizzi V, Ranieri M, di Teo L, Santamato A

Efficacy of low-level laser therapy in the management of neck pain: a systematic review and meta-analysis of randomised placebo or active-treatment controlled trials

Review of laser therapy for neck pain published in a top-tier medical journal.

Published: The Lancet. 2009; 374(9705): 1897–1908. doi: 10.1016/S0140-6736(09)61522-1
Author(s): Chow RT, Johnson MI, Lopes-Martins AB, Bjordal JM

Ga-As (808 nm) laser irradiation enhances ATP production in human neuronal cells in culture

The authors conclude that laser application to NHNP cells significantly increases ATP production which may explain the beneficial effects of low-level laser therapy (LLLT) in stroked rats.

Published: Photomedicine and Laser Surgery. 2007; 25(3): 180-182. doi: 10.1089/pho.2007.2064
Author(s): Oron U, Ilic S. de Taboada L, Streeter J

Mechanisms of low level light therapy

This review paper covers the current theory on basic mechanisms of laser therapy.

Published: Proc. of SPIE Photonics. 2006; 6140: 614001-01-12. doi: 10.1117/12.646294
Author(s): Hamblin MR, Demidova TN

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