Growth factors and cytokines in wound healing

Published:  Wound Repair Regen. 2008 Sep-Oct;16(5):585-601. doi: 10.1111/j.1524-475X.2008.00410.x.

Authors:  Barrientos S, Stojadinovic O, Golinko MS, Brem H, Tomic-Canic M

Summary:  Wound healing is an evolutionarily conserved, complex, multicellular processthat, in skin, aims at barrier restoration. This process involves the coordinatedefforts of several cell types including keratinocytes, fibroblasts, endothelial cells,macrophages, and platelets. The migration, infiltration, proliferation, and differ-entiation of these cells will culminate in an inflammatory response, the formationof new tissue and ultimately wound closure. This complex process is executed andregulated by an equally complex signaling network involving numerous growthfactors, cytokines and chemokines. This article investigates the roles of Growth Factors and numerous cytokines during the wound healing process.

Key words:  Growth factors, wound healing, platelet-rich plasma

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